Preliminary anti-tuberculosis screening of two Nigerian Laggera species (Laggera pterodonta and Laggera aurita)

Dynamic Chiropractic

Peters Oladosu¹  Iliya Ibrahim²  O. Henry Egharevba³  E. Samuel Okhale⁴ 

[1] TM), National Institute for Pharmaceutical Research and Development (NIPRD), Abuja, Nigeria.;Department of Chemistry, University of Abuja, Nigeria.;Department of Medicinal Plant Research and Traditional Medicine (MPR &Department of Microbiology and Biotechnology (M and BT), National Institute for Pharmaceutical Research and Development (NIPRD), Abuja, Nigeria.

关键词: Laggera pterodonta;    Laggera aurita;    anti-tuberculosis.;   

DOI  :  10.5897/JMPR09.434

学科分类：医学（综合）

来源: MPA Media

【 摘 要 】

Crude methanolic extracts of the aerial part of the twoLaggeraspecies (Laggera pterodonta(DC.) Sch. Bip.andLaggera aurita(Linn f.) DC.) from the family Asteraceae (Compositea), found in Nigeria were screened againstMycobacterial bovis(BCG strains). The two extracts were found to be active at minimum inhibitory concentrations (MIC) of 625 µg/ml. Further fractionation and screening of the fractions against BCG shows moderate activity for some of the fractions. The four compounds (crystals) isolated in the process did not show any activity, but are currently being analyzed by spectroscopy for characterization and identification.

【 授权许可】

Unknown