Anti-ulcerogenic activity of Gynura procumbens leaf extract against experimentally-induced gastric lesions in rats

Dynamic Chiropractic

Abdalbasit A. Mariod¹  A. A. Mahmood²  Siddig Ibrahim Abdel-Wahab⁴  Fouad Al-Bayaty⁵ 

[1] Department of Food Science and Technology, College of Agricultural Studies, Sudan University of Science and Technology, P. Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.;Department of Restorative Dentistry, Faculty of Dentistry, University Technology Mara, 40000, Shah Alam, Selangor, Malaysia.;North Sudan.;O. Box 71, Khartoum, 

关键词: Gynura procumbens;    cytoprotection;    gastric ulcer;    histology;    ethanolic extract.;   

DOI  :  10.5897/JMPR10.018

学科分类：医学（综合）

来源: MPA Media

【 摘 要 】

Several plants are used in folk medicine to treat gastrointestinal disorders.Gynura procumbensis a medicinal plant commonly usedin traditional treatment of many aliments. In this study,G. procumbensethanolic leaf extract (GPELE) was used to investigate its gastroprotective effect in adultSprague dawleyrats which were divided into six groups. The rats were orally pre-treated with carboxymethyl cellulose (CMC) solution (ulcer control groups), omeprazole 20 mg/kg (reference group), 50, 100, 200 and 400 mg/kg of GPELE in CMC solution (experimental groups), one hour before oral administration of absolute ethanol to generate gastric mucosal injury. After an additional hour, the rats were sacrificed and the ulcer areas of the gastric walls were determined. The ulcer control group exhibited severe mucosal injury, whereas groups pre-treated with GPELEexhibited significant protection of gastric mucosal injury. These findings were also confirmed by histological studies. Acute toxicity study with a higher dose of 5 g/kg did not manifest any toxicological signs in rats. These results suggest that GPELEpromotes ulcer protection as ascertained grossly by significant reduction of ulcer area, and histologically by comparatively decreases in ulcer areas, reduction or absence of edema and leucocytes infiltration of submucosal layer compared to ulcer control group.

【 授权许可】

Unknown