Anti-HIV-1 reverse transcriptase activities of hexane extracts from some Asian medicinal plants

Dynamic Chiropractic

Supa Hannongbua¹  Supaporn Seetaha²  Parinya Pongsanarakul³  Kun Silprasit⁴ 

[1]Center for Advanced Studies in Tropical Natural Resources, National Research University-Kasetsart University, Kasetsart University, Bangkok, 10900, Thailand, CASTNAR, NRU-KU, Thailand.

[2]Department of Biochemistry, Faculty of Science, Kasetsart University, Bangkean, Bangkok 10900, Thailand.

[3]Department of Chemistry, Faculty of Science, Kasetsart University, Bangkean, Bangkok 10900, Thailand.

[4]Faculty of Environmental culture and Ecotourism, Srinakharinwirot University, Wattana, Bangkok 10110, Thailand.

关键词: Anti-HIV agents;    HIV-1 reverse transcriptase;    inhibitor screening;    PicoGreen.;   

DOI  :  

学科分类：医学（综合）

来源: MPA Media

【 摘 要 】

Numerous herbal remedies against viral infections, including HIV-1, have been used as a part of Asian traditional medicine. However, the viral protein targets for inhibition by these medications are less well identified. HIV-1 reverse transcriptase is one of the targets, since high-efficiency inhibitors such as non-nucleoside HIV-1 reverse transcriptase inhibitor have been successfully used. In this work, hexane extracts of Asian medicinal plants were screened against HIV-1 reverse transcriptase. The results showed that the crude extracts from plantsCinnamomum loureiroi(stem bark), Quercus infectoria(fruit),Plumbago indicaL.(root),Artocarpus heterophyllusLam.(seed),Ocimum sanctumL.(leaves),Allium sativumL.(bulb)andAcorus calamusL.(rhizomes)showed strong HIV-1 reverse transcriptase inhibitory effects. The efficiency of anti-HIV-1RT activity was reported as 50% inhibitory concentrations (IC50). This showed that the hexane crude extracts fromA. calamusL.andA. heterophyllusLam.contained potent activity against HIV-1 RT, with IC50of 32.96 ± 3.17 and 34.69 ± 2.41 µg/ml, respectively.

【 授权许可】

Unknown