Severe aquaporin 4-IgG-positive neuromyelitis optica with disseminated herpes zoster in a pregnant woman successfully treated with intravenous immunoglobulin:

Multiple Sclerosis Journal – Experimental, Translational and Clinical

Toshiyuki Takahashi¹  Teiji Yamamoto²  Chikako Kaneko²  Shakespear Norshalena²  Mario Tsuchiya²  Jin Kubo²  Yuki Matsumoto²  Kazuo Fujihara³ 

[1] Department of Neurology, NHO Yonezawa Hospital, Japan;Department of Neurology, Southern Tohoku General Hospital, Japan;Department of Neurology, Tohoku University Graduate School of Medicine, Japan

关键词: Neuromyelitis optica;    aquaporin-4-IgG;    pregnancy;    intravenous immunoglobulin;    acute treatment;    herpes zoster;   

DOI  :  10.1177/2055217318758119

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

A 26-year-old, 17-week pregnant woman developed aquaporin-4-IgG-positive severe longitudinally extensive transverse myelitis during the course of disseminated herpes zoster and became quadriparetic. She was unresponsive to high-dose intravenous methylprednisolone but became able to walk without assistance after intravenous immunoglobulin. One and a half months later, left optic neuritis developed but her vision improved with intravenous immunoglobulin. The only sequela was left T5 girdle sensation, and she delivered a healthy baby. Intravenous immunoglobulin may be a rescue therapy in aquaporin-4-IgG-positive neuromyelitis optica attacks in pregnant women, especially those with severe infections.

【 授权许可】

CC BY-NC