Processes for design, construction and utilisation of arrays of light-emitting diodes and light-emitting diode-coupled optical fibres for multi-site brain light delivery

The Journal of Engineering

Edward Stuart Boyden¹  Brian Douglas Allen²  Jacob Gold Bernstein²  Alexander A. Guerra³ 

[1] Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA;Department of Brain and Cognitive Sciences and MIT McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA;The MIT Media Lab, Massachusetts Institute of Technology, Cambridge, MA 02139, USA

关键词: thermal design;    low-noise concurrent electrophysiology;    light-emitting diode arrays;    LED-coupled optical fibre arrays;    mechanical design;    optical design;    light-emitting diode-coupled optical fibre arrays;    surgical automation approaches;    patterned light delivery;    optogenetics;    electrical design;    multisite brain light delivery;    genetically targeted cells;    multisite targetable optical devices;   

DOI  :  10.1049/joe.2014.0304

学科分类：工程和技术（综合）

来源: IET

【 摘 要 】

Optogenetics enables light to be used to control the activity of genetically targeted cells in the living brain. Optical fibres can be used to deliver light to deep targets, and light-emitting diodes (LEDs) can be spatially arranged to enable patterned light delivery. In combination, arrays of LED-coupled optical fibres can enable patterned light delivery to deep targets in the brain. Here the authors describe the process flow for making LED arrays and LED-coupled optical fibre arrays, explaining key optical, electrical, thermal and mechanical design principles to enable the manufacturing, assembly and testing of such multi-site targetable optical devices. They also explore accessory strategies such as surgical automation approaches as well as innovations to enable low-noise concurrent electrophysiology.

【 授权许可】

CC BY