Hepatoprotective and toxic characteristics of the whole herb of traditional Tibetan folk medicine Swertia mussotii Franch.

Dynamic Chiropractic

Yuzhi Du¹  Ping Lv²  Hongxia Yang³  Lixin Wei³ 

[1] Graduate University of Chinese Academy of Sciences, Beijing, 100049, People’Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining, Qinghai, 810001, People’s Republic of China.

关键词: Swertia mussotiiFranch.;    Gentianaceae;    Tibetan herb;    extracts;    hepatoprotective activity;    toxicity.;   

DOI  :  10.5897/JMPR10.114

学科分类：医学（综合）

来源: MPA Media

【 摘 要 】

Swertia mussotiiFranch. (SM) (Gentianaceae) was a traditional Tibetan folk herb for hepatitis in the Qinghai-Tibet plateau areas. For understanding the hepatoprotection and toxicity characteristics ofSwertia mussotiiFranch., the whole plant ofSwertia mussotiiwas extracted by water (SME-b) and 75% ethanol (SME-a); then, SME-a was dissolved with water, the supernatant was SME-c, and the sedimentation was SME-d. 17.76% SME-a, 14.48% SME-b, 10.13% SME-c, and 4.35%SME-d were extracted fromSwertia mussotii. These four extracts were evaluated with acute toxicity and hepatoprotective effect on CCl4-induced acute liver damage in mice. The toxic material mainly reside in SME-c and SME-a. The hepatoprotective materials were in SME-a, SME-c and SME-d, while SME-b had no hepatoprotective activities. So, SME-a and SME-c had both the hepatoprotection and toxicity characteristics; SME-b had no toxicity or the hepatoprotection characteristics; only SME-d was hepatoprotective function without toxicity, which could be a good candidate for new drug healing the live disorder.

【 授权许可】

Unknown