Dendrobium moniliforme extract regulates glucose and lipid metabolism through activation of peroxisome proliferator-activated receptor

Dynamic Chiropractic

Goo Yoon¹  Yujung Jung²  Ye Ran Hwang³  Woojung Lee⁴  Ki Sung Kang⁵  Youngsic Jeon⁶ 

[1] College of Pharmacy, Mokpo National University, Muan, 534-729, Korea.;College of Pharmacy, Sookmyung Women’Department of Molecular Cell Biology, Natural Medicine Center, KIST Gangneung Institute, Gangneung, 210-340, Korea.;Samsung Biomedical Research Institute,;s University, Seoul, 140-742, Korea.

关键词: Peroxisome proliferator-activated receptor (PPARα    );    Dendrobium moniliforme;    obesity.;   

DOI  :  10.5897/JMPR12.761

学科分类：医学（综合）

来源: MPA Media

【 摘 要 】

Peroxisome proliferator-activated receptors (PPARs) have been considered as desirable targets for curing metabolic diseases, even though their specific agonists have several side effects. In this study, we demonstrated a novel pharmacological property of methanol extract ofDendrobium moniliforme(DM) on metabolic disorders bothin vitroandin vivo. DM extract and its ethyl acetate (EA) fraction selectively stimulated the transcriptional activity of PPARα and regulated expression of genes involved in lipid metabolism in HepG2 hepatocytes, which led to increased mitochondrial and/or peroxisomal fatty acid β-oxidation. Furthermore, the DM treatment significantly decreased body weight gain and feed efficiency in high-fat diet (HFD) mouse model, which were associated with a significant reduction of total cholesterol and free fatty acid levels in the serum. In addition, DM treatment significantly reduced serum levels of both alanine aminotransferase and aspartate aminotransferase compared to the HFD-induced obese mice. Altogether, our findings strongly suggest that DM and itsEAfraction can improve glucose and lipid impairment in HFD mice model and might be considered as a therapeutic agent that is effective for improving glucose and lipid homeostasis without severe side effects.

【 授权许可】

Unknown