A Case Study of Rat Bite Fever Caused by Streptobacillus moniliformis

Japanese journal of infectious diseases

Yasue Hayakawa¹  Wataru Sugiura²  Kiyofumi Ohkusu³  Jun Suzuki⁴  Masahiro Suzuki⁵ 

[1] Department of Clinical Laboratory, National Hospital Organization Nagoya Medical Center;Department of Immunology and Infectious Diseases, Clinical Research Center, National Hospital Organization Nagoya Medical Center;Department of Microbiology, Tokyo Medical University;Division of General Internal Medicine, National Hospital Organization Nagoya Medical Center;Laboratory and Bacteriology, Aichi Prefectural Institute of Public Health

关键词: Streptobacillus moniliformis;    rat bite fever;    16S rRNA sequencing;   

DOI  :  10.7883/yoken.JJID.2016.270

学科分类：传染病学

来源: National Institute of Infectious Diseases

【 摘 要 】

We report a case of rat bite fever, diagnosed based on positive cultures of Streptobacillus moniliformis from blood and synovial fluid. The patient was a 45-year-old man who presented with history of a rat bite and alcoholic liver cirrhosis. He had been bitten on his third finger by a rat, which was caught in a mousetrap installed in his house. Over the course of approximately 2 weeks after the bite, the patient developed fever, rash, and arthralgia. The patient was admitted to our hospital and treated with a combination of ampicillin-sulbactam, vancomycin (VAN), and minocycline (MIN) antibiotics. Initial culture findings from the Anaerobic/F resin blood culture were positive for gram-negative bacillus after overnight incubation. Thus, S. moniliformis infection was suspected, and administration of VAN and MIN was ceased. On hospital day 8, the treatment was switched to oral amoxicillin-clavulanic acid, and the patient was discharged from the hospital. Subsequently, the pathogen was also detected in synovial fluid and identified as S. moniliformis using 16S rRNA sequencing analysis.

【 授权许可】

Unknown