Influence of Novel Highly Pathogenic Avian Influenza A (H5N1) Virus Infection on Migrating Whooper Swans Fecal Microbiota

Frontiers in Cellular and Infection Microbiology

Liu, Shelan¹  Li, Meng²  Wang, Supen³  Su, Wen⁴  He, Hongxuan⁴  Li, Hongyi⁴  Zhao, Na⁴  Luo, Jing⁴ 

[1] College of Environmental and Resource Sciences, Zhejiang University, China;Department of Infectious Diseases, Zhejiang Provincial Centre for Disease Control and Prevention, China;Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, China;National Research Center for Wildlife-Borne Diseases, Institute of Zoology, Chinese Academy of Sciences, China

关键词: Migrating birds;    Whooper swans;    fecal microbiota;    highly pathogenic avian Influenza A virus;    H5N1;   

DOI  :  10.3389/fcimb.2018.00046

学科分类：生物科学（综合）

来源: Frontiers

【 摘 要 】

The migration of wild birds plays an important role in the transmission and spread of H5 highly pathogenic avian influenza (HPAI) virus, posing a severe risk to animal and human health. Substantial evidence suggests that altered gut microbial community is implicated in the infection of respiratory influenza virus. However the influence of H5N1 infection in gut microbiota of migratory birds remains unknown. In January 2015, a novel recombinant H5N1 virus emerged and killed about 100 migratory birds, mainly including whooper swans in Sanmenxia Reservoir Area of China. Here, we describe the first fecal microbiome diversity study of H5N1-infected migratory birds. By investigating the influence of H5N1 infection on fecal bacterial communities in infected and uninfected individuals, we found that H5N1 infection shaped the gut microbiota composition by a difference in the dominance of some genera, such as Aeromonas and Lactobacillus. We also found a decreased α diversity and increased β diversity in infectious individuals. Our results highlight that increases in changes in pathogen-containing gut communities occur when individuals become infected with H5N1. Our study may provide the first evidence that there are statistical association among H5N1 presence and fecal microbiota compositional shifts, and properties of the fecal microbiota may serve as the risk of gut-linked disease in migrates with H5N1 and further aggravate the disease transmission.

【 授权许可】

CC BY