Alcohol extract of Pterogyne nitens leaves fails to reduce severity of streptozotocin-induced diabetes in rats

Dynamic Chiropractic

Aline de Souza¹  Luis O. Regasini²  Dulce H. Siqueira Silva³  Regina C. Vendramini⁴  Iguatemy L. Brunetti⁵ 

[1] Clinical Analysis Department, School of Pharmaceutical Sciences - UNESP - SãOrganic Chemistry Department, Chemistry Institute - UNESP-São Paulo State University, Rua Francisco Degni s/n - Araraquara, SP, Brasil.;o Paulo State University. Rua Expedicionários do Brasil n. 1621 - Araraquara, SP, Brazil.

关键词: Antidiabetic plant;    alkaline phosphatase;    biochemical markers;    hepato-biliary toxicity marker.;   

DOI  :  10.5897/JMPR10.094

学科分类：医学（综合）

来源: MPA Media

【 摘 要 】

Two constituents ofPterogyne nitensleaves,kaempferitrin, a diglycosylated flavonol, and galegin, a guanidine alkaloid, may be considered likely to exert an antidiabetic effect, on the basis of their chemical structures. Thus, experimentally diabetic rats were treated withP. nitensleaf extract, to observe the effects on biochemical and toxicological marker variables. Streptozotocin-diabetic rats (50 mg/kg body weight) were given ethanolic extract of the leaves (76 mg suspended in 0.5 mL of 10% aqueous glycerine per rat) (DP) by gavage, twice a day for 32 days. Diabetic controls were given 0.5 mL of 10% glycerine (DG), insulin (2.5 U in 0.3 mL s. c.) (DI) or 0.5 mL water (DW). Initial glycemia was 537.11 ± 10.35 mg/dL. Each week or fortnight after the treatment glucose, urea and protein contents were determined in the urine and glycemia and alkaline phosphatase activity in the serum. Except for proteinuria, the results for groups DP, DG and DW all differed significantly (p < 0.05) from those for group DI, which exhibited reduced values of all the other variables. The plant extract neither improved nor worsened the diabetic state of the rats; nor did it give rise to any hepato-biliary toxic effect.

【 授权许可】

Unknown