Staging and surgical approaches in gastric cancer: a clinical practice guideline

Current oncology

G. Knight¹  C.D. Mercer²  L. Klein³  R. Malthaner⁴  R. Cosby⁵  N. Coburn⁶  J. Mamazza⁷  J. Ringash⁸ 

[1] Grand River Regional Cancer Centre;Hotel Dieu Hospital;Humber River Regional Hospital;London Regional Cancer Program;McMaster University;Odette Cancer Centre;Ottawa Civic Hospital;Princess Margaret Hospital

关键词: Gastric cancer;    laparoscopic surgery;    lymph node dissection;    practice guidelines;    staging;    surgical margins;    surgical volumes;    surgery;   

DOI  :  10.3747/co.24.3736

学科分类：肿瘤学

来源: Multimed, Inc.

【 摘 要 】

BackgroundResection is the cornerstone of cure for gastric adenocarcinoma; however, several aspects of surgical intervention remain controversial or are suboptimally applied at a population level, including staging, extent of lymphadenectomy (lnd), minimum number of lymph nodes that have to be assessed, gross resection margins, use of minimally invasive surgery, and relationship of surgical volumes with patient outcomes and resection in stage iv gastric cancer. MethodsLiterature searches were conducted in databases including medline (up to 10 June 2016), embase (up to week 24 of 2016), the Cochrane Library and various other practice guideline sites and guideline developer Web sites. A practice guideline was developed. ResultsOne guideline, seven systematic reviews, and forty-eight primary studies were included in the evidence base for this guidance document. Seven recommendations are presented. ConclusionsAll patients should be discussed at a multidisciplinary team meeting, and computed tomography (ct) imaging of chest and abdomen should always be performed when staging patients. Diagnostic laparoscopy is useful in the determination of M1 disease not visible on ct images. A D2 lnd is preferred for curative-intent resection of gastric cancer. At least 16 lymph nodes should be assessed for adequate staging of curative-resected gastric cancer. Gastric cancer surgery should aim to achieve an R0 resection margin. In the metastatic setting, surgery should be considered only for palliation of symptoms. Patients should be referred to higher-volume centres and those that have adequate support to manage potential complications. Laparoscopic resections should be performed to the same standards as those for open resections, by surgeons who are experienced in both advanced laparoscopic surgery and gastric cancer management.

【 授权许可】

Unknown