Antioxidant and antiproliferative activities of methanolic extracts of Perilla frutescens

Dynamic Chiropractic

En-Shyh Lin¹  Hung-Ju Chou² 

[1]Department of Beauty Science, National Taichung Nursing College, Taichung, Taiwan.

[2]Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

关键词: Perilla frutescens;    methanolicextract;    antioxidant activity;    radical scavenging;    reducing power;    antiproliferative.;   

DOI  :  10.5897/JMPR10.035

学科分类：医学（综合）

来源: MPA Media

【 摘 要 】

Perilla frutescensis a common traditional Chinese medicinal plant used totreat a variety of diseases. The methanolic extracts from different parts ofP. frutescenswere evaluated for their antioxidant and antiproliferative activities. The antioxidant activities ofP. frutescenswere evaluated by using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging methods. Reducing power, metal chelating ability, total phenolic content and total flavonoid content were also detected. In all the tested models, the methanolic extracts of stalk, leaf and seed ofP. frutescensshowed their ability to scavenge the free radicals, reducing power and chelating capacity in a does-dependent manner. The antiproliferative activities of methanolic extracts from different parts ofP. frutescenswere also studied in vitro by usinghumannon-small celllung A549 cancer cells. The methanolic extract of stalk exhibited moderate antiproliferative activity. The methanolic extract of stalk had higher antioxidant and antiproliferative activities than of leaf and seed. These results indicated that stalk ofP. frutescensmight be used as a potential source of natural antioxidants and as an anti-tumor agent.

【 授权许可】

Unknown