First ever isolation of cytotoxic triterpenoid 2-hydroxydiplopterol from plant source

Dynamic Chiropractic

关键词: Arisaema jacquemontii;    cytotoxic triterpenoid 2-hydroxydiplopterol;    isolation.;   

DOI  :  10.5897/JMPR12.1258

学科分类：医学（综合）

来源: MPA Media

【 摘 要 】

Arisaema jacquemontiihave shown medicinal importance and biological activities particularly, its anticancer activity, so we have decided to keep on investigating the plant in term of its chemical constituents. A chemical investigation on the chloroform extract ofA. jacquemontiihave resulted in the isolation of a cytotoxic, triterpenoid 2-hydroxydiplopterol (1), previously reported from the halotolerant, fungal strainaspergillus variecolorB-17. This represents perhaps the first report of cytotoxic compound from plant source. The compound (1) has been identified by multidimensional nuclear magnetic resonance (NMR) spectroscopy and comparison of its spectroscopic data with that reported for the compound. Its exhibited cytotoxicity with IC50value of 22 µM against K 562 cell lines. The cytotoxicity properties of compound 1 were determined by the sulforhodamine B method.

【 授权许可】

Unknown