Neuroprotective effect of salidroside on hemisection-induced spinal cord injury in rats

Dynamic Chiropractic

Xinyu Fan¹  Yueliang Zhu²  Jun Li³ 

[1] Department of Orthopedics, Kuming General Hospital of Chengdu Military Region, Kuming 650032,Yunnan Province, PR China.;Department of Orthopedics, The First General Hospital of Yibin, Yibin 644000, Sichuan Province, PR China.;Department of Orthopedics, The Third Military Medical University, Chongqing 400038, PR China.

关键词: Salidroside;    spinal cord injury (SCI);    oxidation.;   

DOI  :  

学科分类：医学（综合）

来源: MPA Media

【 摘 要 】

The effect of salidroside on hemisection-induced spinal cord injury (SCI) in rats was investigated. The Sprague Dawley (SD) rats were randomly divided into six groups: Sham control group, SCI model group, the methylprednisolone sodium succinate (MPSS) group, the salidroside-low dosage group, the salidroside-moderate dosage group and the salidroside-high dosage group. The SD rats were hemisected at spinal cord at the T8 vertebra to establish SCI models. 24 h after operation, different dosage of salidroside increased the superoxide anion (O2−) level and superoxide dismutase (SOD) activity, and reduced malondialdehyde (MDA) content. Noticeably, salidroside at the 100 mg/kg dosage exhibited similar effects as MPSS, which has been frequently used for clinical acute SCI. These results suggested that salidroside can significantly suppress oxidation in acute SCI.

【 授权许可】

Unknown