Are serum leptin levels a prognostic factor in advanced lung cancer?

Bratislava Medical Journal

C. Anar¹ 

关键词: leptin;    survival;    prognosis.;   

DOI  :  10.4149/BLL_2017_003

学科分类：医学（综合）

来源: AEPress, s.r.o.

【 摘 要 】

AIM: The aim of the present study was to evaluate pre-treatment concentrations of leptin in patients with advanced lung cancer and to investigate possible associations between their levels and clinicopathological variables, response to therapy and overall survival.MATERIAL AND METHODS: There are 71 previously untreated patients with cytological or histological evidence of primary lung cancer who were admitted to the oncology department between November 2013 and August 2014. Forty-five healthy individuals with age, sex and BMI matching the lung cancer patients, were recruited to take part in the study as a control group. Leptin levels were measured quantitatively by using a microELISA kit.RESULTS: The serum leptin levels at diagnosis were significantly lower in lung cancer patients than those in control subjects (4.75±4.91 ng/ml, 9.67±8.02 ng/ml; p

【 授权许可】

CC BY