The enhancement effect of Salvia miltiorrhiza on melanin production of B16F10 melanoma cells

Dynamic Chiropractic

Ming-Shian Hung¹  Yi-Shyan Chen²  Shu-Hua Chiang³ 

[1] Department of Cosmetic Science and Management, Mackay Medicine, Nursing and Management College, 92 Shengjing Road, Beitou, Taipei 11260, Taiwan, Republic of China.;Department of Cosmetic Science, Providence University, 200 Chung-Chi Road, Shalu, Taichung 43301, Taiwan, Republic of China.;Department of Food and Beverage Management, Taiwan Hospitality and Tourism College,268 Chong-Hsing St., Feng-Shan Village, Shou-Feng County, Hualien 974, Taiwan, Republic of China.

关键词: Danshen;    melanin;    melanogenesis;    Salvia miltiorrhiza;    tyrosinase.;   

DOI  :  10.5897/JMPR012.544

学科分类：医学（综合）

来源: MPA Media

【 摘 要 】

Salvia miltiorrhizais a well-known and widely used medicinal plant for the treatment of angina pectoris, hyperlipidemia and acute ischemic stroke. However, no research has described the function ofS. miltiorrhizaon melanogenesis. Therefore, in this study we analyzed the effect ofS. miltiorrhizaleaf extract (SME) on the tyrosinase activity and the production of melanin of melanoma cells. Results indicated that SME at 0.1 mg/ml could enhance mushroom tyrosinase activity up to 132.14 ± 11.89% and increase melanin content up to 121.37 ± 16.57% in B16F10 melanoma cells. Besides, no cytotoxicity was observed when B16F10 cells were treated with SME. For this reason, we suggest that SME could be use for the treatment of hypopigmentation disorder and for development of gray hair preventing agents or self-tanning cosmetics.

【 授权许可】

Unknown