The First Case Report of Cerebral Cyst Infection Due to Helicobacter cinaedi

Japanese journal of infectious diseases

Soichiro Abiko¹  Yoshiko Yamaguchi¹  Yoji Hirayama¹  Itaru Nakamura²  Kiyofumi Ohkusu³  Tetsuya Matsumoto³ 

[1] Department of General Medicine and Primary Care, Tokyo Medical University Hospital;Department of Infectious Disease Medicine, Tokyo Medical University Hospital;Department of Microbiology, Tokyo Medical University

关键词: Helicobacter cinaedi;    cerebral cyst;    bacteremia;    Ommaya reservoir;    lung cancer;   

DOI  :  10.7883/yoken.JJID.2016.031

学科分类：传染病学

来源: National Institute of Infectious Diseases

【 摘 要 】

We report the first case of cerebral cyst infection by Helicobacter cinaedi, a fastidious spiral-shaped gram-negative rod bacterium. A 70-year-old man visited Tokyo Medical University Hospital with persisting fever since 2 weeks. He underwent surgery and radiotherapy for parapharyngeal space squamous cell carcinoma 10 years ago. The radiotherapy resulted in a cerebral cyst as a side effect, and an Ommaya reservoir was inserted into the cyst. Blood culture and analysis of the brain cyst fluid revealed the presence of spiral-shaped gram-negative rod bacteria, which were identified as H. cinaedi by polymerase chain reaction. Initially, we administered clarithromycin (400 mg per day). After H. cinaedi infection was confirmed, the treatment was changed to meropenem (MEPM 6 g per day). The patient was treated for 43 days in the hospital with intravenous meropenem, and his clinical course was satisfactory. On the 44th day, he was discharged and prescribed oral minocycline (MINO 200 mg per day). After discharge, the patient's H. cinaedi infection did not recur. Our case illustrated the wide clinical spectrum of H. cinaedi as well as the effectiveness of antibiotic therapy comprising MERM and MINO for treating central nervous system infection by this organism.

【 授权许可】

Unknown