Cytotoxic saikosaponins from Bupleurum yinchowense

Dynamic Chiropractic

关键词: Bupleurum yinchowense;    umbelliferae;    saikosaponins;    cytotoxic;    3β    16α    23;    28-tetrahydroxy-olean-11;    13(18)-dien-29-oic acid 3-O-β    -D-gluco-pyranosyl-(1→    3)-β    -D-fucopyranoside.;   

DOI  :  10.5897/JMPR12.344

学科分类：医学（综合）

来源: MPA Media

【 摘 要 】

Activity-guided fraction of the ethanolic extract of the root fromBupleurum yinchowenseresulted in the isolation of 13 saikosaponins. Their structures were identified to be saikosaponin a (1), saikosaponin c (2), saikosaponin d (3), saikosaponin b2(4),saikosaponin f(5), saikosaponin b4 (6), 6"-O-acetylsaikosaponin a (7), 3β,16α,23,28-tetrahydroxy-olean-11,13(18)-dien-29-oic acid 3-O-β-D-glucopyranosyl-(1→3)-β-D-fucopyranoside (8), chikusaikosideⅠ(9), saikogenin F (10), saikosaponin e (11), 6"-O-acetylsaikosaponin d (12), saikosaponin 14 (13) on the basis of their spectral data and chemical evidences. Compound 8 is a new natural product and the other 12 compounds were separated from this plant for the first time. Compounds 1 to 10 were evaluatedin vitrofor their inhibitory ability against the growth of human esophageal cancer cell lines (Eca-109), human colon cancer cell lines (W-48), human cervical cancer cell lines (Hela), human ovarian cancer (SKOV3). Compounds 1, 3 and 7 exhibited significant inhibitory activities against the tested cell lines, with the IC50values not more than 15 μg/ml.

【 授权许可】

Unknown