Comparison of in vitro antimicrobial effect of ethanol extracts of Satureja khuzestanica, Rhus coriaria, and Ocimum basilicum L. on Helicobacter pylori

Dynamic Chiropractic

Ahmad Rashidi¹  Mohammad Saleh Hazhir²  Yousef Motaharinia³  Mohammad Ali Rezaee⁴  Siamak Vahedi⁵  Mohammad Saeed Hakhamaneshi⁶  Werya Hosseini⁷ 

[1]Besat Hospital, 

[2]Department of Biochemistry and Nutrition, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.

[3]Department of Immunology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.

[4]Department of 

[5]Internal Medicine, Faculty of medicine, 

[6]Iran.

[7]Kurdistan University of Medical Sciences, Sanandaj, 

关键词: Satureja khuzestanica;    Rhus coriaria;    Ocimum basilicum L.;    H. pylori;    antibacterial effect.;   

DOI  :  10.5897/JMPR11.1725

学科分类：医学（综合）

来源: MPA Media

【 摘 要 】

Helicobacter pyloriis the main reason of gastritis, gastric ulcer and cancer, which cause many therapeutic problems for man, throughout the world. Therefore, the aim of the current study is to compare the antimicrobial effect of the extracts ofSatureja khuzestanica,Rhus coriaria, andOcimum basilicumL.onH. pylori. To isolateH. pylori, sampling was performed in 30 patients of the endoscopy ward of Be’sat Hospital, Sanandaj. Ethanol extracts ofS. khuzestanica,R. coriariaandO. basilicumL.were prepared. Using disc diffusion and agar dilution methods, the antimicrobial effects of the plant extracts againstH. pyloriwere evaluated. Seven strains ofH. pyloriwere isolated from the biopsy samples. The results of disc diffusion demonstrated that the mean diameter of no-growth halo for the discs containing 20 mg ofS. khuzestanica,R. coriariaandO. basilicum L.were ≥ 12.28, ≥ 19.42, and ≥ 11.42 mm, respectively. The values for the discs containing 40 mg of the extracts were ≥ 20.14, ≥ 28.57, and ≥ 13.57 mm, respectively. The mean diameter of no-growth halo for gentamicin (10 μg/ml con.) as the positive control was obtained to be ≥ 37.85 mm. The results of agar dilution method showed that the minimum inhibitory concentration (MIC) of the extracts ofS. khuzestanica,R. coriaria, andO. basilicum L.were 307.14, 214.28, and 392.8 µg/ml, respectively. The study showed that the ethanol extract ofR. coriariaandS. khuzestanicahad antibacterial effect againstH. pylori.

【 授权许可】

Unknown