Heterogeneous Family of Cyclomodulins: Smart Weapons That Allow Bacteria to Hijack the Eukaryotic Cell Cycle and Promote Infections

Frontiers in Cellular and Infection Microbiology

Taieb, Fré⁶  Nicolas, Auré⁶  El-Aouar Filho, Rachid A.⁹  Berkova, Nadia⁹  Goossens, Pierre L.⁹  Le Loir, Yves^1,13  De Carvalho Azevedo, Vasco A.^1,13  Lina, Gerard^1,15  Deplanche, Martine^1,15  lie^2,20  dé^2,20  ric^2,21  De Paula Castro, Thiago L.^2,21 

[1] Escherichia coli, Toulouse, France;Lyon 1, Lyon, France;et de la Recherche MéCHU Purpan USC INRA 1360-CPTP, U1043 Institut National de la SantéCentre National de la Recherche Scientifique, UMR5308, Institut National de la SantéDepartamento de Biologia Geral, LaboratóHistoPathologie et ModèInternational Center for Infectiology Research, Lyon, France;STLO, Agrocampus Ouest Rennes, Institut National de la Recherche Agronomique, Rennes, France;culaire et Cellulaire des Infections àdicale U1111, Ecole Normale Supédicale, Pathogégicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil;les Animaux/Pathogéncias Biolónie Molénie des Toxi-Infections Bactériennes, Institut Pasteur, Paris, France;rieure de Lyon, Universitério de Genética Celular e Molecular (LGCM), Instituto de Ciê

关键词: eukaryotic cell cycle alteration;    colonization;    invasion;    infective efficiency;    reduced host response;    Bacterial Toxins;    Cyclomodulins;   

DOI  :  10.3389/fcimb.2017.00208

学科分类：生物科学（综合）

来源: Frontiers

【 摘 要 】

Some bacterial pathogens modulate signaling pathways of eukaryotic cells in order to subvert the host response for their own benefit, leading to successful colonization and invasion. Pathogenic bacteria produce multiple compounds that generate favorable conditions to their survival and growth during infection in eukaryotic hosts. Many bacterial toxins can alter the cell cycle progression of host cells, impairing essential cellular functions and impeding host cell division. This review summarizes current knowledge regarding cyclomodulins, a heterogeneous family of bacterial effectors that induce eukaryotic cell cycle alterations. We discuss the mechanisms of action of cyclomodulins according to their biochemical properties, providing examples of various cyclomodulins such as cycle inhibiting factor, γ-glutamyltranspeptidase, cytolethal distending toxins, shiga toxin, subtilase toxin, anthrax toxin, cholera toxin, adenylate cyclase toxins, vacuolating cytotoxin, cytotoxic necrotizing factor, Panton-Valentine leucocidin, phenol soluble modulins and mycolactone. Special attention is paid to the benefit provided by cyclomodulins to bacteria during colonization of the host.

【 授权许可】

CC BY