Inhibition of the principal enzymatic and biological effects of the crude venom of Bothrops atrox by plant extracts

Dynamic Chiropractic

o de Moura¹  o²  Rosa H. Veras Mouratilde⁴  Valeria Mouratilde⁵  Ricardo Bezerra de Oliveira⁶  Hipocrates de M. Chalkidis⁷  Luciana A. F. de Sousa⁸  Sergio Pacheco⁸  Ana M. Moura da Silva⁹  Milton Nascimento da Silva^1,12 

[1] - UFOPA, 68035-110 Santaré- UFPA, 66075-110, BeléFederal University of ViçGraduate Program in Chemistry - PPGQ, Laboratory of Liquid Chromatography - LABCROL, Federal University of ParáGraduate Program in Natural Resources from Amazon - PGRNA, Laboratory of Experimental Biology and Bioprospecting - LabBBEx, Federal University of Western ParáImmunopathology laboratory, Instituto Butantan, 05503-900, SãZoological Research Laboratory - LPZ, Integrated College Tapajóm, PA, Brazil.;o Paulo, SP, Brazil.;osa - Av. P. H. Rolfs s/n, 36570-000, Viçosa, MG, Brazil.;s - FIT, 68010-200 Santaré

关键词: Natural inhibitors;    Bothrops atrox;    Bellucia dichotoma;    Connarus favosus;    Plathymenia reticulata;    Philodendron megalophyllum;    Aniba fragrans.;   

DOI  :  10.5897/JMPR2013.5148

学科分类：医学（综合）

来源: MPA Media

【 摘 要 】

This study analyzes the effectiveness of extracts from five plant species used for treating venomous snakebites in the region of Santarém, in central Brazilian Amazonia. The aqueous extracts ofBellucia dichotomaCogn.,Connarus favosusPlanch.,Aniba fragransDucke,Plathymenia reticulataBenth., andPhilodendron megalophyllumSchott were prepared by decoction at 70°C and lyophilized. Inhibition of the enzymatic activity and biological effects of the crude venom ofBothrops atroxwas tested by pre-incubating different concentrations (1:1 to 1:30 venom:extract, w/w) for 30 min at 37°C. These results confirm traditional local knowledge on the anti-toxin powers of the native plants of the Amazon basin and the potential of these extracts as toxin inhibitors and as an alternative or complement for the standard treatment of snakebite based on the application of antisera.

【 授权许可】

Unknown