Blocking LINGO-1 in vivo reduces degeneration and enhances regeneration of the optic nerve:

Multiple Sclerosis Journal – Experimental, Translational and Clinical

Guoqing Sheng¹  Bing Hu²  Dennis Kemper²  Qing-Ling Fu³  Helmut Butzkueven⁴  Melissa M Gresle⁵  Sha Mi⁵  Blake Pepinsky⁶  Trevor J Kilpatrick⁷  Guanrong Huang⁸  Yaou Liu⁹  Qi-Zhu Wu⁹  Kwok-Fai So⁹ 

[1] CAS Key Laboratory of Brain Function and Disease, School of Life Sciences, University of Science and Technology of China, China;Centre for Neuroscience Research, University of Melbourne, Australia;Department of Anatomy and Neuroscience, University of Melbourne, Australia;Department of Discovery Neurobiology, Biogen, USA;Department of Medicine (RMH), University of Melbourne, Australia;Department of Ophthalmology, University of Hong Kong, China;Department of Radiology, Xuanwu Hospital, Capital Medical University, China;Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, China;The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Australia

关键词: Optic neuritis;    optic nerve degeneration;    regeneration;    axons;    retinal ganglion cells;    LINGO-1;    anti-LINGO-1 antibody;    multiple sclerosis;   

DOI  :  10.1177/2055217316641704

学科分类：医学（综合）

来源: Sage Journals

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