In vitro preliminary study of antiprotozoal effect of four medicinal plants from Benin

Dynamic Chiropractic

Marcel KAISER¹  Annelise LOBSTEIN⁵  Latifou LAGNIKA⁷  Bernard WENIGER⁸  Barthelemy ATTIOUA^1,11  Ambaliou SANNI^1,14  Catherine VONTHRON-SENECHEAU^1,15 

[1] d’de Cocody, Abidjan, Côde Pharmacie, Universitéde Strasbourg, France.;Abomey-Calavi, BéInnovation ThéLaboratoire de Biochimie et de Biologie MoléLaboratoire de Chimie Organique Biologique, UFR Sciences des Structures de la MatièLaboratoire de Pharmacognosie et MoléSwiss Tropical and Public Health Institution, Socinstrasse 57, 4002 Basel, Switzerland. University of Basel, Basel, Switzerland.;culaire, Décules Naturelles Bioactives, Laboratoire d’ivoire.;nin.;partement de Biochimie et de Biologie Cellulaire, Universitérapeutique, UMR CNRS-UdS 7200, Facultére et Technologie, Universitéte d'

关键词: Traditional medicine;    antimalarial;    leishmanicidal;    trypanocidal;    Benin.;   

DOI  :  10.5897/JMPR12.253

学科分类：医学（综合）

来源: MPA Media

【 摘 要 】

A total of fourteen extracts with different polarity obtained from four speciesCrataeva religiosa, Baillonella toxisperma, Boswellia dalzieliiandKhaya senegalensis,traditionally used in Benin to treat malaria were tested for theirin vitroantiprotozoal activity towardsPlasmodium falciparum, Trypanosoma rhodesiense, Trypanosoma cruziandLeishmania donovani. Selected plants were extracting with cyclohexane, methylene chloride, ethyl acetate, ether diethyl, methanol and ethanol. Tested extracts showed moderate to good antiparasitic effects at two different concentrations (9.6 and 1.6 µg/ml). Manyextracts showed appreciable growth inhibition at 9.5 µg/ml. Ethanol extract ofB. dalzieliiwas the most active againstT. rhodesienseandL. donovaniwith growth inhibition percentage of 100 and 95.6%, respectively. Sevenout of fourteenextracts also showed interesting growth inhibition percentage from 99 to 87%, onP. falciparumat 9.6 µg/ml. The most interesting activity againstL. donovaniwas observed with the cyclohexane extract ofC. religiosawith growth inhibition value of 55% at 1.6 µg/ml.

【 授权许可】

Unknown