Ecological Restoration of Antibiotic-Disturbed Gastrointestinal Microbiota in Foregut and Hindgut of Cows

Frontiers in Cellular and Infection Microbiology

Su, Huawei¹  Yan, Hui²  Liu, Jingjing³  Ji, Shoukun³  Wang, Yajing³  Alugongo, Gibson M.³  Shi, Haitao³  Li, Shengli³  Jiang, Tao³  Cao, Zhijun³  Guo, Chunyan³ 

[1] Laboratory of Animal Nutrition, College of Animal Science and Technology, Shihezi University, China;Laboratory of Animal Nutrition, College of Animal Science, Tarim University, China;State Key Laboratory of Animal Nutrition, Beijing Engineering Technology Research Center of Raw Milk Quality and Safety Control, College of Animal Science and Technology, China Agricultural University, China

关键词: Gut Microbiota;    antibiotics;    microbial ecology;    restoration;    foregut;    Hindgut;   

DOI  :  10.3389/fcimb.2018.00079

学科分类：生物科学（综合）

来源: Frontiers

【 摘 要 】

Antibiotically disturbed gastrointestinal microbiota needs a long period time to be restored to normal, which may cause a series of problems to the host. The understanding of restoration of the biased microbiota by antibiotics remains largely unknown. Here, we investigated the microbiota shift in foregut (rumen) and hindgut (rectum) of lactating cows after antibiotics exposure as well as after antibiotics withdrawal with (Microbiota transplantation, MT group) or without (Control, CON group) microbiota transplantation. We were able to demonstrate that microbiota in both foregut and hindgut significantly changed after 3 or 14 days of antibiotics exposure, and the changes persisted over long period of time (>18 days) after withdrawing the antibiotics. We further observed a faster restoration of microbiota in both foregut and hindgut of MT group than CON group, microbiota in foregut was mainly benefited from microbiota transplantation by restoring the alpha-diversity as well as within-group similarity, while microbiota in hindgut was primarily benefited from microbiota transplantation by reestablishing the co-occurrence network (nodes number, edges number, density, modularity as well as closeness centrality). These results together expanded our understanding of restoration of the biased microbiota by antibiotics, and may also be instructive to deal with the delayed microbiota restoration at least in cows.

【 授权许可】

CC BY