A Trypanosoma brucei Kinesin Heavy Chain Promotes Parasite Growth by Triggering Host Arginase Activity

PLoS Pathogens

Thomas A. Wynn¹  Jan Van Den Abbeele¹  Andrew N. J. McKenzie¹  Philippe Holzmuller¹  Silla Semballa²  Guy Caljon²  Pierrette Courtois³  Philippe Vincendeau⁴  Patrick De Baetselier⁵  Sylvie Daulouède⁵  Benoît Stijlemans⁵  Luc Vanhamme⁵  Etienne Pays⁶  Géraldine De Muylder⁷  Michael P. Barrett⁷  Laurence Lecordier⁷  Pierrick Uzureau⁷  Luke Barron⁸  Yannick Morias⁸  Michel Hérin⁸  Jillian L. Barlow⁸  Alain Beschin⁹ 

[1] Cellular and Molecular Immunology Unit, Vrije Universiteit Brussel (VUB), Brussels, Belgium;Department of Biomedical Sciences, Veterinary Protozoology Unit, Prins Leopold Institute of Tropical Medicine Antwerp, Antwerp, Belgium;Department of Pathology, Institut de Pathologie et de Génétique, Gosselies, Belgium;Glasgow Polyomics Facility, University of Glasgow, Glasgow, United Kingdom;Laboratoire de Parasitologie, UMR 177 IRD CIRAD Université de Bordeaux, Bordeaux, France;Laboratory of Molecular Biology, Medical Research Council, Cambridge, United Kingdom;Laboratory of Molecular Parasitology, IBMM, Université Libre de Bruxelles (ULB), Gosselies, Belgium;Myeloid Cell Immunology Laboratory, VIB Brussels, Brussels, Belgium;The Wellcome Trust Centre for Molecular Parasitology, Institute for Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

关键词: Parasitic diseases;    Trypanosoma;    Bone marrow cells;    Trypanosoma brucei gambiense;    Trypanosoma brucei;    Immunoprecipitation;    Pathogenesis;    Gene expression;   

DOI  :  10.1371/journal.ppat.1003731

学科分类：生物科学（综合）

来源: Public Library of Science

【 授权许可】

CC BY