Basic principles and applications of iontophoresis for cutaneous penetration of drugs

Quimica nova

Gelfuso, Guilherme Martins¹  Gratieri, Taís¹  Lopez, Renata Fonseca Vianna¹ 

[1] Universidade de São Paulo, Ribeirão Preto, Brasil

关键词: iontophoresis;    topic and transdermaldelivery;    electrorepulsion.;   

DOI  :  10.1590/S0100-40422008000600040

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Physicochemical constraints severely limit thenumber of molecules that can be considered as candidates for transdermal delivery.Iontophoresis is a non-invasive technique in which a weak electric current isused to enhance the penetration of molecules into or through the skin. In thisreview the underlying mechanisms that drive iontophoresis and the impact ofkey experimental parameters – namely, formulation, drug concentration and pH– on iontophoretic delivery efficiency are discussed. In the final section somedevices that are currently commercialized are also described.

【 授权许可】

CC BY