SYNTHESIS AND ANTIFUNGAL ACTIVITY OF DIARYL HYDRAZONES FROM 2,4-DINITROPHENYLHYDRAZINE

Journal of The Chilean Chemical Society

ORTIZ, SERGIO¹  KESTERNICH, VÍCTOR¹  NELSON, RONALD¹  PÉREZ-FEHRMANN, MARCIA²  MARCOURT, LAURENCE²  CHRISTEN, PHILIPPE³ 

[1] Universidad Católica del Norte, Antofagasta, Chile;University of Geneva, Geneva, Switzerland;University of Lausanne, Lausanne, Suiza

关键词: Antifungal Activity;    Diarylhydrazones;    Schiff bases.;   

DOI  :  10.4067/S0717-97072016000300015

学科分类：化学（综合）

来源: Sociedad Chilena de Quimica

【 摘 要 】

A new series of diarylhydrazones derived from 2,4-dinitrophenylhydrazine were synthesized via condensation with aromatic aldehydes whose structures have been determined by mass spectrometry, infrared spectroscopy, and nuclear magnetic resonance spectra. Yields were 50-99%. All compounds were screened in vitro for their antifungal activity. Preliminary results indicated that compounds 3g and 3h exhibited promising antifungal potency. Understanding of the structure of these compounds establishes a preliminary structure-activity relationship to form the basis of further investigation.

【 授权许可】

Unknown