Direct Presentation Is Sufficient for an Efficient Anti-Viral CD8+ T Cell Response

PLoS Pathogens

Felicia Roscoe¹  Sanda Remakus¹  Ren-Huan Xu¹  Xueying Ma¹  Luis J. Sigal¹ 

[1] Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America

关键词: Antigen-presenting cells;    Major histocompatibility complex;    Spleen;    T cells;    Vaccinia virus;    Bone marrow cells;    Antigen presentation;    Cytotoxic T cells;   

DOI  :  10.1371/journal.ppat.1000768

学科分类：生物科学（综合）

来源: Public Library of Science

【 摘 要 】

The extent to which direct- and cross-presentation (DP and CP) contribute to the priming of CD8+ T cell (TCD8+) responses to viruses is unclear mainly because of the difficulty in separating the two processes. Hence, while CP in the absence of DP has been clearly demonstrated, induction of an anti-viral TCD8+ response that excludes CP has never been purposely shown. Using vaccinia virus (VACV), which has been used as the vaccine to rid the world of smallpox and is proposed as a vector for many other vaccines, we show that DP is the main mechanism for the priming of an anti-viral TCD8+ response. These findings provide important insights to our understanding of how one of the most effective anti-viral vaccines induces immunity and should contribute to the development of novel vaccines.

【 授权许可】

CC BY