The structure and function of complex Halobacterium salinarum metabolic network

International Journal of Physical Sciences

X. D. Liu¹ 

关键词: Average path length;    complex networks;    degree distribution;    giant strong component;    metabolic network;    modularity;    scale-free;    small-world;    systems biology.;   

DOI  :  

学科分类：物理（综合）

来源: Academic Journals

【 摘 要 】

Genome-scale metabolic networks are widely used in industrial and medical biotechnology and complex networks methods are increasingly becoming important in the investigation of these models. The present paper performed a study ofHalobacterium salinarummetabolic network by structural and functional analysis. First, we extracted high-qualityH. salinarummetabolic network model from a recent reconstruction and based on its “bow tie” structure, we then extracted and studied the giant strong component (GSC) with its functional significance. Global structural properties such as average path length, degree distribution and self-similar exponent were computed and it indicated that the GSC is also a small-world, scale-free and self-similar network. Furthermore, the top 10 hub metabolites and functional modules in giant strong component were studied with their biological significance.

【 授权许可】

CC BY