From Molecular Genetics to Phylodynamics: Evolutionary Relevance of Mutation Rates Across Viruses

PLoS Pathogens

Rafael Sanjuán¹ 

[1] Institut Cavanilles de Biodiversitat i Biologia Evolutiva, Universitat de València, Paterna, Valencia, Spain

关键词: Viral evolution;    Evolutionary rate;    Hepatitis C virus;    Evolutionary immunology;    Microbial mutation;    Genome evolution;    Molecular evolution;    dsRNA viruses;   

DOI  :  10.1371/journal.ppat.1002685

学科分类：生物科学（综合）

来源: Public Library of Science

【 摘 要 】

Although evolution is a multifactorial process, theory posits that the speed of molecular evolution should be directly determined by the rate at which spontaneous mutations appear. To what extent these two biochemical and population-scale processes are related in nature, however, is largely unknown. Viruses are an ideal system for addressing this question because their evolution is fast enough to be observed in real time, and experimentally-determined mutation rates are abundant. This article provides statistically supported evidence that the mutation rate determines molecular evolution across all types of viruses. Properties of the viral genome such as its size and chemical composition are identified as major determinants of these rates. Furthermore, a quantitative analysis reveals that, as expected, evolution rates increase linearly with mutation rates for slowly mutating viruses. However, this relationship plateaus for fast mutating viruses. A model is proposed in which deleterious mutations impose an evolutionary speed limit and set an extinction threshold in nature. The model is consistent with data from replication kinetics, selection strength and chemical mutagenesis studies.

【 授权许可】

CC BY