Molecular evolution and expression profile of the chemerine encoding gene RARRES2 in baboon and chimpanzee

Biological research: BR

Diana Resé¹  Anthony G. Comuzzie³  Oralia Barboza-Quintana⁴  Ricardo Canales-Del-Castillo⁵  a de Lourdes Garza-Rodrí⁷  Á⁷  Rafael Gonzá⁷  a Del Refugio Rocha-Pizañ⁷  ctor Manuel Treviñ⁸  Hugo Alberto Barrera-Saldañ^1,11  a Elizabeth Tejero^1,13  Laura Elia Martí^1,14  ndez-Pé^1,15  n Delgado-Enciso^1,16  Irá^1,17  guez-Sá^1,18  Ivá^2,21  Shelley A. Cole^2,22  a^2,23  lez-Alvarez^2,24  guez^2,25  ngel Lugo-Trampe^2,25  m Pablo Rodrí^2,26  Natalia E. Schlabritz-Loutsevitch^2,27  rez^2,28  Ví^2,29  Mario Moises-Alvarez^2,29  o-Alvarado^2,29  Marí^2,29  Raquel Garza-Guajardo^2,29  nez-De-Villarreal^2,29  nchez^2,29 

[1] Eleuterio GonzáAuxology and Metabolism Working Group, Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, USA;Centro Mesoamericano de Estudios en Salud PúInstituto Nacional de Medicina GenóTecnolóTexas Tech University Health Sciences Center at the PB, Odessa, USA;Universidad AutóUniversidad de Colima, Facultad de Medicina, Colima, Méa Patolóa, Monterrey, Méblica y Desastres (CEMESAD, Nodo Tapachula), Universidad Autógica y Citopatologígicas, San Nicolágico de Monterrey campus Monterrey, Monterrey, Mélez, Departamento de Genémica y Medicina Molecular, Monterrey, Mémica. Perifén Tlalpan, Mén, Facultad de Ciencias Biolón, Facultad de Medicina, Departamento de Anatomín, Facultad de Medicina, Departamento de Bioquín, Hospital Universitario Dr. Josénoma de Chiapas, Tapachula, Ménoma de Guadalajara, Facultad de Medicina, Zapopan, Ménoma de Nuevo Leórico Sur 4809, Colonia Arenal Tepepan, Delegaciós de los Garza, Mética, Monterrey, México

关键词: Retinoic acid receptor;    Responder protein;    Primate;    Chemerin;    TIG2;    Tazarotene-induced gene 2 protein;    Gene expression;   

DOI  :  10.1186/s40659-015-0020-0

学科分类：生物科学（综合）

来源: BioMed Central

【 摘 要 】

Chemerin, encoded by the retinoic acid receptor responder 2 (RARRES2) gene is an adipocytesecreted protein with autocrine/paracrine functions in adipose tissue, metabolism and inflammation with a recently described function in vascular tone regulation, liver, steatosis, etc. This molecule is believed to represent a critical endocrine signal linking obesity to diabetes. There are no data available regarding evolution of RARRES2 in non-human primates and great apes. Expression profile and orthology in RARRES2 genes are unknown aspects in the biology of this multigene family in primates. Thus; we attempt to describe expression profile and phylogenetic relationship as complementary knowledge in the function of this gene in primates. To do that, we performed A RT-PCR from different tissues obtained during necropsies. Also we tested the hypotheses of positive evolution, purifying selection, and neutrality. And finally a phylogenetic analysis was made between primates RARRES2 protein. RARRES2 transcripts were present in liver, lung, adipose tissue, ovary, pancreas, heart, hypothalamus and pituitary tissues. Expression in kidney and leukocytes were not detectable in either species. It was determined that the studied genes are orthologous. RARRES2 evolution fits the hypothesis of purifying selection. Expression profiles of the RARRES2 gene are similar in baboons and chimpanzees and are also phylogenetically related.

【 授权许可】

CC BY