Lytic Promoters Express Protein during Herpes Simplex Virus Latency

PLoS Pathogens

Tiffany A. Russell¹  David C. Tscharke¹ 

[1] John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia

关键词: Viral persistence;    latency;    Neurons;    Viral gene expression;    Neuronal death;    T cells;    Cytotoxic T cells;    Gene expression;    Protein expression;   

DOI  :  10.1371/journal.ppat.1005729

学科分类：生物科学（综合）

来源: Public Library of Science

【 摘 要 】

Herpes simplex virus (HSV) has provided the prototype for viral latency with previously well-defined acute or lytic and latent phases. More recently, the deep quiescence of HSV latency has been questioned with evidence that lytic genes can be transcribed in this state. However, to date the only evidence that these transcripts might be translated has come from immunological studies that show activated T cells persist in the nervous system during latency. Here we use a highly sensitive Cre-marking model to show that lytic and latent phases are less clearly defined in two significant ways. First, around half of the HSV spread leading to latently infected sites occurred beyond the initial acute infection and second, we show direct evidence that lytic promoters can drive protein expression during latency.

【 授权许可】

CC BY