Mechanisms involved in reproductive damage caused by gossypol in rats and protective effects of vitamin E

Biological research: BR

ia T Santana¹  Paulo F V Bizerra¹  Marieli Guelfi¹  André¹  Marco A Tavares¹  Hyllana C D Medeiros¹ 

[1] Laboratory of Metabolic and Toxicological Biochemistry, UNESP-Univ Estadual Paulista, Dracena, Brazil

关键词: Gossypol;    Fertility;    Oxidative stress;    Bioenergetics;    Antioxidant system;    Vitamin E;   

DOI  :  10.1186/s40659-015-0026-7

学科分类：生物科学（综合）

来源: BioMed Central

【 摘 要 】

Gossypol is a chemical present in the seeds of cotton plants (Gossypium sp.) that reduces fertility in farm animals. Vitamin E is an antioxidant and may help to protect cells and tissues against the deleterious effects of free radicals. The aim of this study was to evaluate the mechanisms of reproductive toxicity of gossypol in rats and the protective effects of vitamin E. Forty Wistar rats were used, divided into four experimental groups (n = 10): DMSO/saline + corn oil; DMSO/saline + vitamin E; gossypol + corn oil; and gossypol + vitamin E. Fertility was significantly reduced in male rats treated with gossypol in that a significant decrease in epididymal sperm count was observed (P 

【 授权许可】

CC BY