Suppression of Plant Resistance Gene-Based Immunity by a Fungal Effector

PLoS Pathogens

Petra M. Houterman¹  Ben J. C. Cornelissen¹  Martijn Rep¹ 

[1] Plant Pathology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands

关键词: Plant fungal pathogens;    Tomatoes;    Plant pathology;    Fungal genetics;    Plant bacterial pathogens;    Fungi;    Gene prediction;    Xylem;   

DOI  :  10.1371/journal.ppat.1000061

学科分类：生物科学（综合）

来源: Public Library of Science

【 摘 要 】

The innate immune system of plants consists of two layers. The first layer, called basal resistance, governs recognition of conserved microbial molecules and fends off most attempted invasions. The second layer is based on Resistance (R) genes that mediate recognition of effectors, proteins secreted by pathogens to suppress or evade basal resistance. Here, we show that a plant-pathogenic fungus secretes an effector that can both trigger and suppress R gene-based immunity. This effector, Avr1, is secreted by the xylem-invading fungus Fusarium oxysporum f.sp. lycopersici (Fol) and triggers disease resistance when the host plant, tomato, carries a matching R gene (I or I-1). At the same time, Avr1 suppresses the protective effect of two other R genes, I-2 and I-3. Based on these observations, we tentatively reconstruct the evolutionary arms race that has taken place between tomato R genes and effectors of Fol. This molecular analysis has revealed a hitherto unpredicted strategy for durable disease control based on resistance gene combinations.

【 授权许可】

CC BY