Nuclear Hormone Receptor Regulation of MicroRNAs Controls Innate Immune Responses in C. elegans

PLoS Pathogens

Li-Shun Wang¹  San-Feng Han¹  Chen-Xi He²  Yong-Xu Zhao³  Quan-Li Zou³  Feng Liu³  Ratni Saini³  Bao-Xue Ge⁴  Hans-Joachim Knölker⁴  Li-Jun Luo⁵ 

[1] Department of Chemistry, Technical University of Dresden, Dresden, Germany;Graduate School of Chinese Academy of Sciences, Beijing, China;Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai JiaoTong University School of Medicine, Shanghai, China;Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao-Tong University School of Medicine, Shanghai, China;Shanghai Key Laboratory of Tuberculosis, Clinical and Translational Research Center, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China

关键词: Pseudomonas aeruginosa;    Caenorhabditis elegans;    MicroRNAs;    RNA interference;    Immune response;    Gene expression;    Pathogens;    Innate immune system;   

DOI  :  10.1371/journal.ppat.1003545

学科分类：生物科学（综合）

来源: Public Library of Science

【 摘 要 】

Nuclear hormone receptors respond to small molecules such as retinoids or steroids and regulate development. Signaling in the conserved p38/PMK-1 MAP kinase pathway regulates innate immunity. In this study, we show that the Caenorhabditis elegans nuclear receptor DAF-12 negatively regulates the defense against pathogens via the downstream let-7 family of microRNAs, which directly target SKN-1, a gene downstream of PMK-1. These findings identify nuclear hormone receptors as components of innate immunity that crosstalk with the p38/PMK-1 MAP kinase pathway.

【 授权许可】

CC BY