The Great Escape: Viral Strategies to Counter BST-2/Tetherin

PLoS Pathogens

Jean K. Gustin¹  Mandana Mansouri¹  Klaus Früh¹  Ashlee V. Moses¹  Kasinath Viswanathan¹  Janet L. Douglas¹ 

[1] Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America

关键词: HIV-1;    Virions;    HIV-2;    SIV;    Ebola virus;    Kaposi's sarcoma-associated herpesvirus;    HIV;    Lysosomes;   

DOI  :  10.1371/journal.ppat.1000913

学科分类：生物科学（综合）

来源: Public Library of Science

【 摘 要 】

The interferon-induced BST-2 protein has the unique ability to restrict the egress of HIV-1, Kaposi's sarcoma–associated herpesvirus (KSHV), Ebola virus, and other enveloped viruses. The observation that virions remain attached to the surface of BST-2-expressing cells led to the renaming of BST-2 as “tetherin”. However, viral proteins such as HIV-1 Vpu, simian immunodeficiency virus Nef, and KSHV K5 counteract BST-2, thereby allowing mature virions to readily escape from infected cells. Since the anti-viral function of BST-2 was discovered, there has been an explosion of research into several aspects of this intriguing interplay between host and virus. This review focuses on recent work addressing the molecular mechanisms involved in BST-2 restriction of viral egress and the species-specific countermeasures employed by various viruses.

【 授权许可】

CC BY