Differential expression of upstream stimulatory factor (USF) 2 variants in eutopic endometria from women with endometriosis: estradiol regulation

Biological research: BR

Jazmin Castro¹  Paulina Hidalgo¹  Hugo Sovino¹  Ariel Fuentes¹  Pamela Inostroza¹  n Araya¹  Germá¹  M. Angé²  Reinaldo Gonzá²  lica Boric³  lez-Ramos³ 

[1] Faculty of Medicine, Institute of Maternal and Child Research, University of Chile, Santiago, Chile;San Borja-Arriarán Clinical Hospital, Santiago, Chile

关键词: USF2;    GPER1;    Endometriosis;    Eutopic endometrium;    Estrogen receptor;    Estrogen receptor specific agonists;    SF-1;    P450Arom;   

DOI  :  10.1186/s40659-015-0047-2

学科分类：生物科学（综合）

来源: BioMed Central

【 摘 要 】

Endometriosis, pro-inflammatory and invasive benign disease estrogen dependent, abnormally express in endometria the enzyme P450Arom, positively regulated by steroid factor-1 (SF-1). Our objective was to study the nuclear protein contents of upstream stimulating factor 2 (USF2a and USF2b), a positive regulator of SF-1, throughout the menstrual cycle in eutopic endometria from women with and without (control) endometriosis and the involvement of nuclear estrogen receptors (ER) and G-coupled protein estrogen receptor (GPER)-1. Upstream stimulating factor 2 protein contents were higher in mid (USF2b) and late (USF2a and USF2b) secretory phase in eutopic endometria from endometriosis than control (p 

【 授权许可】

CC BY