FREE RADICAL SCAVENGING, IMMUNOMODULATORY ACTIVITY AND CHEMICAL COMPOSITION OF LUFFA ACUTANGULA VAR: AMARA (CUCURBITACEAE) PERICARP

Journal of The Chilean Chemical Society

SANJAY J., SURANA¹  MOHAN G., KALASKAR¹ 

[1] Patel institute of Pharmaceutical Education and Research, Shirpur, India

关键词: Luffa acutangulavar. amara;    pericarp;    antioxidant;    immunomodulator.;   

DOI  :  10.4067/S0717-97072014000100012

学科分类：化学（综合）

来源: Sociedad Chilena de Quimica

【 摘 要 】

The Luffa acutangula Var.amara (Cucurbitaceae) is climbing shrub; commonly known as wild ridgegourd. Its aerial parts are used traditionally in diverse health ailments. Foursuccessive extracts of L. amara pericarp (LAP) were evaluated for antioxidantusing in vitro for DPPH, ABTS, superoxides radical, reducing power andphosphomolybdenum assay. The bioactive ethanol extract was evaluated for immunomodulatoryactivity by in vivo phagocytosis using carbon clearance and neutrophiladhesion test. The bioactive ethanolic extracts showed potent in vitroantioxidant ability, increased phagocytic index (0.028 ± 0.002), andincreased the % neutrophil adhesion (24.63 ± 0.87%). Furthermore, thepotent plant phenolics such as gallic acid and p-hydroxybenzoicacid were isolated and identified spectroscopically. The presence of these plantphenolics and like constituents would be responsible for their potent antioxidantand immunomodulatory activity.

【 授权许可】

Unknown