DEVELOPMENT OF N-PHENYL-3-PYRIDIN-2-YL IMINO DERIVATIVES AS ANTICOAGULANTS POTENTIAL FACTOR VIIA INHIBITORS

Journal of The Chilean Chemical Society

CHOUDHARI, PRAFULLA B¹  BHATIA, MANISH S¹ 

[1] Bharati Vidyapeeth College of pharmacy Kolhapur, Kolhapur, India

关键词: Anticoagulants;    Factor VIIa Inhibition;    Docking;    QSAR. ;    INTRODUCTION;   

DOI  :  10.4067/S0717-97072013000200005

学科分类：化学（综合）

来源: Sociedad Chilena de Quimica

【 摘 要 】

The ability of the body to maintain the flow of blood following vascular injury is an important process for the survival. Normally the process of blood clotting and then the subsequent dissolution of the clot, following repair of the injured tissue, is known as hemostasis. Anticoagulants are widely utilized in the treatment of all type of thromboembolism. The present communication deals with the design and docking studies of a series of N-Phenyl-3-Pyridin-2-yl imino analogs and their screening anticoagulants and virtually confirming the mechanism of action as factor VIIa Inhibitors. The compounds were synthesized in excellent yields (70-80%) and the structures were established on the basis of consistent IR, 1H NMR, Mass spectroscopy and elemental analysis. All the synthesized compounds were found to exhibit profound anti coagulant activity.

【 授权许可】

Unknown