PARAFAC: a chemometric tool for multi-dimensional data treatment. Applications in direct determination of drugs in human plasma by spectrofluorimetry

Quimica nova

Poppi, Ronei J.¹  Trevisan, Marcello G.¹  Sena, Marcelo M.² 

[1] Universidade Estadual de Campinas, Campinas;Universidade Estadual de Goiás, Anápolis

关键词: parallel factor analysis;    human blood;    molecular fluorescence.;   

DOI  :  10.1590/S0100-40422005000500032

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Since the lastdecade, the combined use of chemometrics and molecular spectroscopic techniqueshas become a new alternative for direct drug determination, without the needof physical separation. Among the new methodologies developed, the applicationof PARAFAC in the decomposition of spectrofluorimetric data should be highlighted.The first objective of this article is to describe the theoretical basis ofPARAFAC. For this purpose, a discussion about the order of chemometric methodsused in multivariate calibration and the development of multi-dimensional methodsis presented first. The other objective of this article is to divulge for theBrazilian chemical community the potential of the combination PARAFAC/spectrofluorimetryfor the determination of drugs in complex biological matrices. For this purpose,two applications aiming at determining, respectively, doxorrubicine and salicylatein human plasma are presented.

【 授权许可】

CC BY