PREFORMULATION STUDIES AND PREPERATION OF DITHRANOL LOADED SOLID LIPID NANOPARTICLES

International Journal of Biomedical Research

Vimal Kumar Shahwal¹ 

[1] T.I.T. College of Pharmacy, Anand Nagar, P.B. No. 24, Bhopal- 462021(M.P.), India

关键词: Dithranol;    Psoriasis;    Solid Lipid Nanoparticle;    Preformulation Studies;   

DOI  :  10.7439/ijbr.v3i7.332

学科分类：基础医学

来源: Scholar Science Journals

【 摘 要 】

Dithranol belongs to the keratolytic category, which is widely used drug in the treatment of psoriasis. The drug is practically insoluble in water. Many conventional dosage forms for psoriasis treatment have been have been formulated earlier, but they did not show good results. Hence in the present study, it was attempted to formulate dithranol in the form of solid lipid nanoparticle. Solid lipid  nanoparticles of dithranol were obtained by adaption of lipid dispersion method. Preformulation studies were performed to check the compatibility of drug and excepient for the preparation of formulation by DSC and no interaction was found. Solubility study, partition coefficient determination, UV analysis, HPLC study, FTIR study were also performed. After the preformulation studies Dithranol loaded solid lipid nanoparticles was also prepared. Hence it was concluded that solid lipid nanoparticle of dithranol could be formulated.

【 授权许可】

CC BY