Bacterial Flagella: Twist and Stick, or Dodge across the Kingdoms

PLoS Pathogens

Yannick Rossez¹  Nicola J. Holden¹  Ashleigh Holmes¹  Eliza B. Wolfson²  David L. Gally² 

[1] Cellular and Molecular Sciences, James Hutton Institute, Dundee, United Kingdom;Division of Infection and Immunity, The Roslin Institute, University of Edinburgh, Easter Bush, United Kingdom

关键词: Flagella;    Flagellin;    Mucus;    Pattern recognition receptors;    Plant bacterial pathogens;    Salmonella typhimurium;    Toll-like receptors;    Host-pathogen interactions;   

DOI  :  10.1371/journal.ppat.1004483

学科分类：生物科学（综合）

来源: Public Library of Science

【 摘 要 】

The flagellum organelle is an intricate multiprotein assembly best known for its rotational propulsion of bacteria. However, recent studies have expanded our knowledge of other functions in pathogenic contexts, particularly adherence and immune modulation, e.g., for Salmonella enterica, Campylobacter jejuni, Pseudomonas aeruginosa, and Escherichia coli. Flagella-mediated adherence is important in host colonisation for several plant and animal pathogens, but the specific interactions that promote flagella binding to such diverse host tissues has remained elusive. Recent work has shown that the organelles act like probes that find favourable surface topologies to initiate binding. An emerging theme is that more general properties, such as ionic charge of repetitive binding epitopes and rotational force, allow interactions with plasma membrane components. At the same time, flagellin monomers are important inducers of plant and animal innate immunity: variation in their recognition impacts the course and outcome of infections in hosts from both kingdoms. Bacteria have evolved different strategies to evade or even promote this specific recognition, with some important differences shown for phytopathogens. These studies have provided a wider appreciation of the functions of bacterial flagella in the context of both plant and animal reservoirs.

【 授权许可】

CC BY