Survey of Hepatitis B virus infection and risk factors among pregnant women at public hospital in Ethiopia

International Journal of Biomedical Research

Zelalem Desalegn¹  Wudma Alemu²  Adane Mihret³  Wondmagegn Tamiru⁴  Mengistu Yilma⁵  Abdisa Boka⁶  Yehenew Asemamaw⁷  Habtamu Bedimo Beyene⁸  Abebe Ejigu⁹  Yimer Seid^1,10 

[1] Department of Microbiology, Immunology and Parasitology, School of Medicine, Addis Ababa University, Addis Ababa,;School of Allied health sciences, Addis Ababa University;School of Medicine, Addis Ababa universityArmauer Hansen Research Institute;School of Pharmacy, Addis Ababa University;School of Public health , Addis Ababa University;School of allied health sciences, Addis Ababa University;School of medicine, Addis Ababa University;School of medicine, Addis Ababa university;School of pharmacy, Addis Ababa University;School of public health, Addis Ababa University

关键词: Hepatitis B;    Pregnancy;    Prevalence of HBsAg;    Risk factors;    Ethiopia;   

DOI  :  10.7439/ijbr.v7i7.3363

学科分类：基础医学

来源: Scholar Science Journals

【 摘 要 】

Background: Hepatitis B is a global public health problem and a major cause of liver disease, including chronic hepatitis, cirrhosis, and liver cancer. Pregnant women with hepatitis B virus infection are a reservoir for the virus and do have high potential to transmit it to their fetuses and newborns. The objective of the study was to investigate seroprevalence of hepatitis B surface antigen and assess risk factors among pregnant women.Methods: Institution based cross-sectional study was conducted from July to September 2014 among pregnant women in Ethiopia. A pretested structured questionnaire was employed to collect data on socio-demographic and potential risk factors for HBV infection. A blood sample was collected and tested for the presence of hepatitis B surface antigen using Enzyme Linked Immunosorbent Assay kit. Obtained data were evaluated by frequency, logistic regression analyses, and a significance level of 5 % (? = 0.05) was established.Result: Of the total pregnant women, 11(5.4%) of the study participants were positive for HBsAg. The majority (40.1%) of participants were in age group 25-29 years. The prevalence of HBV infection was higher above 20 years of age. Our finding revealed that none of the study participants were aware of their HBV serostatus. Seropositivity for hepatitis B surface antigen was statistically associated with history of abortion (AOR: 6; 95% CI :( 1.39-27.69); P-value: 0.017), surgery (AOR: 5;95% CI: 1.04-24.31; P-value: 0.045) and family history for hepatitis (AOR: 11; 95% CI (1.63 80.44); P-value: 0.014).Conclusion: According to the research findings, there was an intermediate endemicity of hepatitis B virus infection. The finding revealed that history of abortion, surgery and family history for hepatitis were the major risk factors for the high prevalence of hepatitis B infection in the study area.Keywords: Hepatitis B, Pregnancy, Prevalence of HBsAg, Risk factors, Ethiopia

【 授权许可】

CC BY