Multifunctional drugs: monoamine oxidase and α-synuclein as targets for the treatment of Parkinson's disease

Quimica nova

Bezerra Netto, Heleno J. C.¹  Follmer, Cristian² 

[1] Instituto Nacional de Propriedade Industrial, Rio de Janeiro, Brasil;Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil

关键词: monoamine oxidase;    α;    -synuclein;    Parkinson's disease.;   

DOI  :  10.1590/S0100-40422013000200017

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Parkinson's disease (PD) is a neurodegenerative disorder associated to selective degeneration of dopaminergic neurons caused by an intricate relationship among dopamine metabolism, oxidative stress and α-synuclein fibrillation. Most therapies for PD have focused on dopamine replacement through the use of both monoamine oxidase inhibitors (MAOIs) and dopamine precursor L-dopa. Interestingly, certain MAOIs have a broad spectrum of action including anti-fibrillogenic properties in α-synuclein aggregation. Herein we revisit the chemical properties of MAOIs and their action on important targets associated with PD, notably α-synuclein fibrillation and dopamine metabolism, discussing the strategies associated with the development of multi-target drugs for neurodegenerative diseases.

【 授权许可】

CC BY