Plant and Animal Pathogen Recognition Receptors Signal through Non-RD Kinases

PLoS Pathogens

Pamela Ronald¹  Christopher Dardick² 

[1] Department of Plant Pathology, University of California Davis, Davis, California, United States of America;United States Department of Agriculture, Agricultural Research Service, Appalachian Fruit Research Station, Kearneysville, West Virginia, United States of America

关键词: Rice;    Immune receptor signaling;    Arabidopsis thaliana;    Protein kinase signaling cascade;    Transcription factors;    Tyrosine kinases;    Innate immune system;    Protein domains;   

DOI  :  10.1371/journal.ppat.0020002

学科分类：生物科学（综合）

来源: Public Library of Science

【 摘 要 】

Plants and animals mediate early steps of the innate immune response through pathogen recognition receptors (PRRs). PRRs commonly associate with or contain members of a monophyletic group of kinases called the interleukin-1 receptor-associated kinase (IRAK) family that include Drosophila Pelle, human IRAKs, rice XA21 and Arabidopsis FLS2. In mammals, PRRs can also associate with members of the receptor-interacting protein (RIP) kinase family, distant relatives to the IRAK family. Some IRAK and RIP family kinases fall into a small functional class of kinases termed non-RD, many of which do not autophosphorylate the activation loop. We surveyed the yeast, fly, worm, human, Arabidopsis, and rice kinomes (3,723 kinases) and found that despite the small number of non-RD kinases in these genomes (9%–29%), 12 of 15 kinases known or predicted to function in PRR signaling fall into the non-RD class. These data indicate that kinases associated with PRRs can largely be predicted by the lack of a single conserved residue and reveal new potential plant PRR subfamilies.

【 授权许可】

CC BY