HIV-1 Capture and Transmission by Dendritic Cells: The Role of Viral Glycolipids and the Cellular Receptor Siglec-1

PLoS Pathogens

Javier Martinez-Picado¹  Nuria Izquierdo-Useros¹  Hans-Georg Kräusslich²  Paul J. McLaren³  Amalio Telenti³  Maier Lorizate⁴ 

[1]AIDS Research Institute IrsiCaixa, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain

[2]Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany

[3]Institute of Microbiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland

[4]Unidad de Biofisica (CSIC-UPV/EHU) and Departamento de Bioquímica, Universidad del Pais Vasco, Bilbao, Spain

关键词: HIV-1;    Sphingolipids;    Dendritic cells;    Exosomes;    T helper cells;    Cell membranes;    Pattern recognition receptors;    Viral structure;   

DOI  :  10.1371/journal.ppat.1004146

学科分类：生物科学（综合）

来源: Public Library of Science

【 摘 要 】

Dendritic cells (DCs) are essential in order to combat invading viruses and trigger antiviral responses. Paradoxically, in the case of HIV-1, DCs might contribute to viral pathogenesis through trans-infection, a mechanism that promotes viral capture and transmission to target cells, especially after DC maturation. In this review, we highlight recent evidence identifying sialyllactose-containing gangliosides in the viral membrane and the cellular lectin Siglec-1 as critical determinants for HIV-1 capture and storage by mature DCs and for DC-mediated trans-infection of T cells. In contrast, DC-SIGN, long considered to be the main receptor for DC capture of HIV-1, plays a minor role in mature DC-mediated HIV-1 capture and trans-infection.

【 授权许可】

CC BY