Post-exposure treatment of Ebola virus using passive immunotherapy: proposal for a new strategy

Journal of venomous animals and toxins

Leslie V Boyer¹  Jean-Philippe Chippaux²  n⁴  Alejandro Alagó⁵ 

[1] Institut de Recherche pour le DéUMR 216, Mother and Child Facing Tropical Diseases, Research Institute for Development (IRD), Cotonou, Benin, and School of Pharmacy, Paris Descartes University, Paris, France;Venom Immunochemistry, Pharmacology and Emergency Response (VIPER) Institute, University of Arizona, Tucson, USA;nin;veloppement (IRD), Cotonou, Bé

关键词: Ebola;    Epidemics;    Immunotherapy;    Prophylaxis;    Africa;   

DOI  :  10.1186/s40409-015-0003-1

学科分类：药理学

来源: BioMed Central

【 摘 要 】

Better treatments are urgently needed for the management of Ebola virus epidemics in Equatorial Africa. We conducted a systematic review of the literature on the use of passive immunotherapy for the treatment or prevention of Ebola virus disease. We placed findings from this review into the context of passive immunotherapy currently used for venom-induced disease, and recent improvements in manufacturing of polyvalent antivenom products. Passive immunotherapy appears to be one of the most promising specific treatments for Ebola. However, its potential has been incompletely evaluated, considering the overall experience and recent improvement of immunotherapy. Development and use of heterologous serum derivatives could protect people exposed to Ebola viruses with reasonable cost and logistics. Hyperimmune equine IgG fragments and purified polyclonal whole IgG deserve further consideration as treatment for exposure to the Ebola virus.

【 授权许可】

CC BY