APPLICATION OF SBA-15 FUNCTIONALIZED SULFONIC ACID (SBA-Pr-SO3H) AS AN EFFICIENT NANOREACTOR IN THE ONE-POT SYNTHESIS OF PYRIDO[2,3-d]PYRIMIDINE

Journal of The Chilean Chemical Society

ASADI, SHIMA¹  GHOLAMZADEH, PARISA¹  ZIARANI, GHODSI MOHAMMADI¹  SOORKI, ALI ABOLHASANI²  BADIEI, ALIREZA³ 

[1] Alzahra University, Tehran, Iran;Shahid Beheshti University, Tehran, Iran;University of Tehran, Tehran, Iran

关键词: SBA-;    Pr-;    SO3H;    Pyrido[;    2;    3-;    d];    pyrimidine compound;    Green synthesis;    Antibiotic.;   

DOI  :  10.4067/S0717-97072015000200024

学科分类：化学（综合）

来源: Sociedad Chilena de Quimica

【 摘 要 】

Sulfonic acid functionalized nanoporous silica (SBA-Pr-SO3H) with a pore size of 6 nm was synthesized using surface modification of Santa Barbara Amorphous (SBA-15). It is a solid acid hexagonally nano-reactor with high surface area and is reusable, high selective, non-corrosiveness which can easily isolate from the products. An efficient and green one-pot three component reaction was developed for the synthesis of pyrido[2,3-d]pyrimidine derivatives via a simple, mild and effective solvent free reaction of 4(6)-aminouracil, barbituric acid and aromatic aldehydes in the presence using SBA-Pr-SO3H. In this reaction, SBA-Pr-SO3H was an effective nano-catalyst which gave the products in good to high yields in a shorter reaction time compared to the other published reports. Some of the products were strong antibiotics against Bacillus subtilis and Staphylococcus aureus.

【 授权许可】

Unknown