Journal of The Chilean Chemical Society | |
APPLICATION OF SBA-15 FUNCTIONALIZED SULFONIC ACID (SBA-Pr-SO3H) AS AN EFFICIENT NANOREACTOR IN THE ONE-POT SYNTHESIS OF PYRIDO[2,3-d]PYRIMIDINE | |
ASADI, SHIMA1  GHOLAMZADEH, PARISA1  ZIARANI, GHODSI MOHAMMADI1  SOORKI, ALI ABOLHASANI2  BADIEI, ALIREZA3  | |
[1] Alzahra University, Tehran, Iran;Shahid Beheshti University, Tehran, Iran;University of Tehran, Tehran, Iran | |
关键词: SBA-; Pr-; SO3H; Pyrido[; 2; 3-; d]; pyrimidine compound; Green synthesis; Antibiotic.; | |
DOI : 10.4067/S0717-97072015000200024 | |
学科分类:化学(综合) | |
来源: Sociedad Chilena de Quimica | |
【 摘 要 】
Sulfonic acid functionalized nanoporous silica (SBA-Pr-SO3H) with a pore size of 6 nm was synthesized using surface modification of Santa Barbara Amorphous (SBA-15). It is a solid acid hexagonally nano-reactor with high surface area and is reusable, high selective, non-corrosiveness which can easily isolate from the products. An efficient and green one-pot three component reaction was developed for the synthesis of pyrido[2,3-d]pyrimidine derivatives via a simple, mild and effective solvent free reaction of 4(6)-aminouracil, barbituric acid and aromatic aldehydes in the presence using SBA-Pr-SO3H. In this reaction, SBA-Pr-SO3H was an effective nano-catalyst which gave the products in good to high yields in a shorter reaction time compared to the other published reports. Some of the products were strong antibiotics against Bacillus subtilis and Staphylococcus aureus.
【 授权许可】
Unknown
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