INHIBITION OF QUORUM SENSING BY DRIMANE LACTONES FROM CHILEAN FLORA

Journal of The Chilean Chemical Society

PAZ, CRISTIAN¹  SILVA, MARIO²  BECERRA, JOSɲ  SOSSA, KATHERINE²  URRUTIA, HOMERO²  CÁRCAMO, GERARDO² 

[1] Universidad de la Frontera, Chile;University of Concepción, Chile

关键词: Quorum sensing;    Chromobacterium violaceum;    Drimys winteri;    Drimane sesquiterpenes.;   

DOI  :  10.4067/S0717-97072014000300021

学科分类：化学（综合）

来源: Sociedad Chilena de Quimica

【 摘 要 】

Fifteen native Chilean plants were evaluated against the quorum sensing (QS) biosensor AI-1, Chromobacterium violaceum ATCC 12472. Three extracts showed inhibitory activity of QS: Drymis winteri J.R, Psoralea glandulosa L and Peumus boldus. Purification of secondary metabolites from barks of Drimys winteri showed that drimane sesquiterpenes were the main compounds in the tree. Polygodial, drimenol, isodrimeninol, drimenin, isodrimenin, cinnamolide and valdiviolide were isolated and evaluated in QS inhibition assays. Two α,β unsaturated lactones, cinnamolide and valdiviolide, with the carbonyl on position 12 of the drimane skeleton were found to be inhibitors of QS; other drimane lactones were not active.

【 授权许可】

Unknown