DNA damage induced by the autoxidation of S(IV) in the presence of transition metal ions

Quimica nova

Coichev, Nina¹  Moreno, Ruben G. M.¹  Medeiros, Marisa H. G.¹  Alipázaga, María V.¹ 

[1] Universidade de São Paulo, São Paulo, Brasil

关键词: DNA cleavage;    oxysulfur radical;    transition metal ions.;   

DOI  :  10.1590/S0100-40422006000500032

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

The oxidationof sulfite catalyzed by transition metal ions produces reactive oxysulfur speciesthat can damage plasmid and isolated DNA in vitro. Among the four DNA bases,guanine is the most sensitive to one-electron oxidation promoted by the speciesformed in the autoxidation of sulfite (HSO5–, HO•,SO3•–, SO4•– and SO5•–)due to its low reduction potential and ability to bind transition metal ionscapable to catalyze oxidative processes. Some oxidative DNA lesions are promutagenicand oxidative DNA damage is proposed to play a crucial role in certain humanpathologies, including cancer.

【 授权许可】

CC BY